With a female bass player who shares vocals with a male front man, and the soft-loud-soft thing, they obviously invite comparisons to the Pixies. But they remind me more of Smashing Pumpkins or a poppier, more structured Sonic Youth. But never mind comparisons, they stand on their own.
Anyway, if you're into that sort of thing, go to their website and check them out. I especially recommend the "Lazy Eye" video, but the video for "Kissing Families" is pretty cool, too. (I'd embed them, but they don't offer the option.)